In the 15th century, an orphan named Anna lives inside the formidable walls of Constantinople. She learns to read and finds what might be the last copy of a centuries-old book, the story of Aethon, who longs to be turned into a bird so that he can fly to a utopian paradise in the sky. Outside the walls is Omeir, a village boy, conscripted with his beloved oxen into the army that will lay siege to the city. His path and Anna’s will cross. In the present day, in a library in Idaho, octogenarian Zeno rehearses children in a play adaptation of Aethon’s story. Tucked among the library shelves is a bomb, planted by a troubled, idealistic teenager, Seymour. And in a not-so-distant future, on the interstellar ship Argos, Konstance is alone in a vault, copying on scraps of sacking the story of Aethon, told to her by her father.

The astrobiologist Theo Byrne searches for life throughout the cosmos while single-handedly raising his unusual nine-year-old, Robin, following the death of his wife. Robin is a warm, kind boy who spends hours painting elaborate pictures of endangered animals. He’s also about to be expelled from third grade for smashing his friend in the face. As his son grows more troubled, Theo hopes to keep him off psychoactive drugs. He learns of an experimental neurofeedback treatment to bolster Robin’s emotional control, one that involves training the boy on the recorded patterns of his mother’s brain.

Alice, a novelist, meets Felix, who works in a warehouse, and asks him if he’d like to travel to Rome with her. In Dublin, her best friend, Eileen, is getting over a break-up and slips back into flirting with Simon, a man she has known since childhood. Alice, Felix, Eileen and Simon are still young, but life is catching up with them. They desire each other, they delude each other, they get together, they break apart. They have sex, they worry about sex, they worry about their friendships and the world in which they live. Are they standing in the last lighted room before the darkness, bearing witness to something? Will they find a way to believe in a beautiful world?

Whether seeking knowledge, riches or a better life, the characters in this debut collection are united by a quest for lasting value, as they ask how we should treat our world, our work, our selves, and each other in both past and present. A vainglorious mine owner dreams of harnessing all of nature to the machinery of commerce. Two women hunt rare butterflies in a pre-First World War landscape already experiencing the first bites of biodiversity loss. A young man tracks down the father who abandoned him inside a festival exhibit. A rural Welsh community is fascinated and angered by glimpses of its invisible, wealthy neighbors.

This is the true story of Eleanor Henderson’s 20-year marriage, which was defined by her husband Aaron’s chronic illness. One day, out of nowhere, a rash appeared on Aaron’s arms. Soon, it had morphed into painful lesions covering his body. Eleanor was as baffled as the doctors. There was no obvious diagnosis, let alone a cure. And as years passed and the lesions gave way to Aaron’s increasingly disturbed concerns about the source of his sickness, the husband she loved seemed to unravel before her eyes. A new fissure ruptured in their marriage, and new questions piled onto old ones: Where does physical illness end and mental illness begin? Where does one person end and another begin? And how do we exist alongside someone else’s suffering?

An interpreter has come to The Hague to escape New York and work at the International Court. A woman of many languages and identities, she is looking for a place to finally call home. She's drawn into simmering personal dramas: her lover, Adriaan, is separated from his wife but still entangled in his marriage. Her friend, Jana, witnesses a seemingly random act of violence, a crime the interpreter becomes increasingly obsessed with as she befriends the victim's sister. And she's pulled into an explosive political controversy when she’s asked to interpret for a former president accused of war crimes. Soon she’s pushed to the precipice, where betrayal and heartbreak threaten to overwhelm her, forcing her to decide what she wants from her life.

Samantha Raymond's life has begun to come apart: her mother is ill, her teenage daughter is increasingly remote, and at 52 she finds herself staring into "the Mids" --- that hour of supreme wakefulness between three and four in the morning in which women of a certain age suddenly find themselves contemplating motherhood, mortality and, in this case, the state of our unraveling nation. When she falls in love with a beautiful, decrepit house in a hardscrabble neighborhood in Syracuse, she buys it on a whim and flees her suburban life --- and her family --- as she grapples with how to be a wife, a mother and a daughter in a country that is coming apart at the seams.

It’s 1953, and Simon Putnam has just been hired by a distinguished New York publishing firm. But his first assignment --- editing The Vixen, the Patriot and the Fanatic, a lurid bodice-ripper improbably based on the recent trial and execution of Ethel and Julius Rosenberg --- makes him question the cost of admission. Simon has a secret that, at the height of the Red Scare and the McCarthy hearings, he cannot reveal: his beloved mother was a childhood friend of Ethel Rosenberg’s. As the confluence of sex, money, politics and power spirals out of Simon’s control, he must face what he’s lost by exchanging the loving safety of his middle-class Jewish parents’ Coney Island apartment for the witty, whiskey-soaked orbit of his charismatic boss.

Joan has spent a lifetime enduring the cruelties of men. But when one of them commits a shocking act of violence in front of her, she flees New York City in search of Alice, the only person alive who can help her make sense of her past. In the sweltering hills above Los Angeles, Joan unravels the horrific event she witnessed as a child --- that has haunted her every waking moment --- while forging the power to finally strike back.

In a tiny settlement on the west coast of Greenland, 11-year-old Aleq and his best friend, frequent trespassers at a mining site exposed to mountains of long-buried and thawing permafrost, carry what they pick up back into their village. PHASE SIX follows Aleq, one of the few survivors of the initial outbreak, through his identification and radical isolation as the likely index patient. While he shoulders both a crushing guilt for what he may have done and the hopes of a world looking for answers, we also meet two Epidemic Intelligence Service investigators dispatched from the CDC --- Jeannine, an epidemiologist and daughter of Algerian immigrants, and Danice, an M.D. and lab wonk. As they attempt to head off the cataclysm, Jeannine does what she can to sustain Aleq.