High school English teacher Polly Goodman can talk about everything and anything with the women in her book club, which is why they’ve become her closest friends and, along with her veterinarian husband, the bedrock of her life. Her students, her fraught relationship with her mother, her struggles with IVF --- Polly’s book club friends have heard about it all. But when they give Polly an ancestry test kit as a joke, the results match her with a stranger. It is clear to Polly that this match is a mistake, but still she cannot help but comb through her family history for answers. Then, when it seems that the book club circle of four will become three, Polly learns how friendships can change your life in the most profound ways.

Radically open-minded, formidably strong, and unusually clear-eyed about herself and others, Evelyn Bednarz has always been a misfit. She's easily bored, unsuited to life at school, asks odd questions about faith and time, and sees through conventions that others take for granted. Seeking to be true to herself, she hitchhikes across the American West taking odd jobs. In distant Tibet, another life unfolds as remote from Evelyn’s as can be: the life of a boy named Tsering, raised as a Buddhist monk in the mountains of Tibet, who eventually becomes a high lama. And yet, their lives are strangely linked --- as Evelyn discovers when a trio of Buddhist lamas show up at her door to announce that her five-year-old son, Cliff, is the seventh reincarnation of the illustrious Norbu Rinpoche, recently deceased. The lamas’ visit sets off a family crisis and a media firestorm over Cliff’s future.

In the fall of her senior year of college, our narrator meets two star students from her 17th-Century Lit class: Sam and Yash. The boys invite her into their intoxicating world of academic fervor, rapid-fire banter and raucous card games. They nickname her Jordan, and she quickly discovers the pleasures of friendship, love and her own intellectual ambition. But youthful passion is unpredictable, and soon she finds herself at the center of a charged and intricate triangle. As graduation comes and goes, choices made will alter these three lives forever. Decades later, the vulnerable days of Jordan's youth seem comfortably behind her. But when a surprise visit and unexpected news bring the past crashing into the present, she returns to a world she left behind and must confront the decisions and deceptions of her younger self.

2014: At a dinner for close friends and colleagues, renowned poet Francis Blundy honors his wife’s birthday by reading aloud a new poem dedicated to her, “A Corona for Vivien.” Little does anyone gathered around the candlelit table know that for generations to come, people will speculate about the message of this poem, a copy of which has never been found and remains an enduring mystery. 2119: Just over 100 years in the future, much of the western world has been submerged by rising seas following a catastrophic nuclear accident. Thomas Metcalfe, a lonely scholar and researcher, longs for the early 21st century as he chases the ghost of one poem, “A Corona for Vivien.” When he stumbles across a clue that may lead to the elusive poem’s discovery, a story is revealed of entangled loves and a brutal crime that destroys his assumptions about people he thought he knew intimately well.

The Bradford-Shmulkin family is falling apart as the pressures of life in an unstable America are fraying their bonds. There's Daddy, a struggling, cash-thirsty editor whose Russian heritage gives him a surprising new currency in the upside-down world of 21st-century geopolitics; his wife, Anne Mom, a progressive, underfunded blue blood from Boston who's barely holding the household together; their son, Dylan, whose blond hair and Mayflower lineage provide him pride of place in the newly forming American political order; and young Vera, half-Jewish, half-Korean and wholly original. Vera wants only three things in life: to make a friend at school; for Daddy and Anne Mom to stay together; and to meet her birth mother, Mom Mom, who at last will tell Vera the secret of who she really is and how to ensure love's survival in this great, mad, imploding world.

Abe Winter and Ruth Warneke were never meant to be together --- at least if you ask Ruth. Yet their catastrophic blind date in college evolved into a 70-year marriage and a life on a farm on Bainbridge Island with their hens and beloved Labrador, Megs. Through the years, the Winters have fallen in and out of lockstep, and from their haunting losses and guarded secrets, a dependable partnership has been forged. But when Ruth’s loose tooth turns out to be something much more malicious, the beautiful, reliable life they’ve created together comes to a crisis. As Ruth struggles with her crumbling independence, Abe must learn how to take care of her while their three living children question his ability to look after his wife. And once again, the couple has to reconfigure how to be there for each other.

Anna Williams-Bonner has taken care of business. That is to say, she’s taken care of her husband, bestselling novelist Jacob Finch Bonner, and laid to rest those anonymous accusations of plagiarism that so tormented him. Now she is living the contented life of a literary widow, enjoying her husband’s royalty checks in perpetuity. But for the second time in her life, a work of fiction intercedes, and this time it’s her own debut novel, The Afterword. When Anna publishes her book and indulges in her own literary acclaim, she begins to receive excerpts of a novel she never expected to see again, a novel that should no longer exist. Someone out there knows far too much: about her late brother, her late husband, and just possibly...Anna herself. What does this person want, and what are they prepared to do?

Flight attendant Allegra Patel loves her job, but today is her 28th birthday and she’d rather not be placating a plane full of passengers unhappy about a long delay. There’s the well-dressed man in seat 4C desperate not to miss his daughter’s musical. A harried mother frantically tries to keep her toddler and baby quiet. Honeymooners still in their wedding finery dream of their new lives, while a chatty emergency room nurse dreams of retirement. Suddenly, a woman traveling alone stands. She walks down the aisle making predictions about how and when passengers will die. Some dismiss her, they don’t believe in psychics. Some are delighted with her prophecies. Their lives supposedly will be long. Others are appalled. Then, a few months later, the first prediction comes true.

Before Jodie Rattler became a star, she was a girl growing up in St. Louis. One day in 1955, when she was just six years old, her uncle Drew took her to the racetrack, where she got lucky --- and that roll of two-dollar bills she won has never since left her side. Jodie thrived in the warmth of her extended family, and then --- through a combination of hard work and serendipity --- she started a singing career, which catapulted her from St. Louis to New York City, from the English countryside to the tropical beaches of St. Thomas, from Cleveland to Los Angeles, and back again. Jodie comes of age in recording studios, backstage and on tour, and she tries to hold her own in the wake of Janis Joplin, Joan Baez, Judy Collins and Joni Mitchell. Yet it feels like something is missing. Could it be true love? Or is that not actually what Jodie is looking for?

When Annie Brown dies suddenly, her husband, children and closest friend are left to find a way forward without the woman who has been the linchpin of all their lives. Bill is overwhelmed without his beloved wife, and Annemarie wrestles with the bad habits her best friend had helped her overcome. And Ali, the eldest of Annie’s children, has to grow up overnight, to care for her younger brothers and even her father, and to puzzle out for herself many of the mysteries of adult life. Over the course of the next year, what saves them all is Annie --- ever-present in their minds, loving but not sentimental, caring but nobody’s fool, a voice in their heads that is funny, sharp and remarkably clear. The power she has given to those who loved her is the power to go on without her. The lesson they learn is that no one beloved is ever truly gone.