In his last years, Sherlock Holmes has abandoned his strict method of logic for the practice of spiritualism. When Lord Carnarvon dies unexpectedly, barely two months after opening the tomb of Tutankhamun, Holmes blames his death and a string of others on an ancient curse. Dr. Watson, never one for the supernatural, decides to finally part ways with the formerly great detective. However, shortly after his departure, Lord Carnarvon’s daughter, Lady Evelyn, approaches Watson with a plea: accompany Holmes to Tutankhamun’s tomb to uncover the truth of her father’s death. But much to his displeasure, there’s a third member of their company --- Mrs. Estelle Roberts, who communicates with the dead. The trio must band together to unravel the extraordinary secret of the boy king and the treasure missing from his tomb that men have killed for.

When Sherlock Holmes finds himself chasing an art dealer through the streets of Paris, he’s certain he’s smoked out one of the principals of a cunning forgery ring responsible for the theft of some of the Louvre’s greatest masterpieces. But he doesn’t know that the dealer, Theo Van Gogh, is rushing to the side of his brother, who lies dying of a gunshot wound in Auvers. He doesn’t know that the dealer’s brother is a penniless misfit artist named Vincent, known to few and mourned by even fewer. Officialdom pronounces the death a suicide, but a few minutes at the scene convinces Holmes it was murder. And he’s bulldog-determined to discover why a penniless painter who harmed no one had to be killed --- and who killed him.