Genoa, Italy, 1946. Vincenzo and Giovanna fall in love at 21. The son of a count and the daughter of a tailor, they belong to opposing worlds. Despite this, the undeniable spark between them quickly burns into a deep and passionate relationship spent exploring each other’s minds, bodies and their city --- until shifts in political power force them each to choose a side and commit what the other believes is a betrayal, shattering the bright future they dreamed of together. New York, 2017. Cassandra and Luca are in love. Although neither quite fits with the other's family, Cass and Luca have always felt like a perfect match for each other. But when Luca, an artist, convinces his grandfather and Cass’ grandmother to pose for a painting, past and present collide and reveal a secret that changes everything.

Emily has come a long way since she lost her two passions 15 years ago: music and Rob. She's a psychologist at NYU who helps troubled college students like the one she once was. Together with her caring doctor husband, Ezra, she has a beautiful life. They're happy. They hope to start a family. But when a tragic event in Emily's present too closely echoes her past, and parts of her story that she'd hoped never to share come to light, her perfect life is suddenly upturned. Then Emily hears a song on the radio about the woman who got away. The melody and voice are hauntingly familiar. Could it be? As Emily's past passions come roaring back into her life, she'll find herself asking: Who is she meant to be? Who is she meant to love?

Nina Gregory has always been a good daughter. Raised by her father, owner of New York City's glamorous Gregory Hotels, Nina was taught that family, reputation and legacy are what matter most. And Tim --- her devoted boyfriend and best friend since childhood --- feels the same. But when Nina's father dies, he leaves behind a secret that shocks Nina to her core. As her world falls apart, Nina begins to see the men in her life --- her father, her boyfriend and, unexpectedly, her boss, Rafael --- in a new light. Soon Nina finds herself caught between the world she loves and a passion that could upend everything.

Lucy and Gabe meet as seniors at Columbia University on a day that changes both of their lives forever. Together, they decide they want their lives to mean something. When they meet again a year later, it seems fated --- perhaps they’ll find life’s meaning in each other. But then Gabe becomes a photojournalist assigned to the Middle East, and Lucy pursues a career in New York. What follows is a 13-year journey of dreams, desires, jealousies, betrayals and, ultimately, love. Was it fate that brought them together? Is it choice that has kept them away? Their journey takes Lucy and Gabe continents apart, but never out of each other’s hearts.