Because they are two sets of twins, the four Latimer sisters are as close as can be. Together they decide to enroll in a training program for nurses --- a new option for women of their time, who previously have been largely limited to the role of wives, and preferably mothers. As the sisters become immersed in hospital life and the demands of their training, they meet people and encounter challenges that spark new maturity and independence.

In the sleepy college town of Holloman, Connecticut, in 1969, two anonymous male corpses turn up, emaciated and emasculated. After connecting the victims to four other bodies, Sergeant Delia Carstairs and Lieutenant Abe Goldberg realize that Holloman has a psychopathic killer on the loose. Police Captain Carmine Delmonico’s team begins to circle a trio of eccentrics, who share family ties, painful memories, and a dark past.

When Chubb University biochemist Millie Hunter notices that a deadly neurotoxin is missing from her laboratory refrigerator, she immediately goes to her father, Holloman, Connecticut's Chief Medical Examiner. They both know that the situation is grave; the poison shuts down the nervous system and is virtually impossible to stop. Soon, as bodies pile up and the coroner keeps pointing to the neurotoxin, Captain Carmine Delmonico must find the killer fast.

In 1968, the leafy Holloman suburb of Carew is being terrorized by a series of vicious and systematic rapes. When finally one victim goes to the police, the rapist escalates to murder. It’s up to Captain Carmine Delmonico to solve this seemingly impossible case.