Forensic pathologist Kay Scarpetta has come almost full circle, returning to Virginia as the chief medical examiner, the state where she launched her storied career. Just weeks on the job, she’s called to a scene by railroad tracks where a woman’s body has been shockingly displayed, her throat cut down to the spine. At the same time, a catastrophe occurs in a top-secret laboratory in outer space, endangering at least two scientists aboard. Appointed to the highly classified Doomsday Commission that specializes in sensitive national security cases, Scarpetta is summoned to the White House and tasked with finding out exactly what happened. But even as she works the first potential crime scene in space remotely, an apparent serial killer strikes again very close to home.