Gifty is a sixth-year PhD candidate in neuroscience at the Stanford University School of Medicine studying reward-seeking behavior in mice and the neural circuits of depression and addiction. Her brother, Nana, was a gifted high school athlete who died of a heroin overdose after an ankle injury left him hooked on OxyContin. Her suicidal mother is living in her bed. Gifty is determined to discover the scientific basis for the suffering she sees all around her. But even as she turns to the hard sciences to unlock the mystery of her family's loss, she finds herself hungering for her childhood faith and grappling with the evangelical church in which she was raised, whose promise of salvation remains as tantalizing as it is elusive.

Ghana, 18th century: Two half sisters, Effia and Esi, are born into different villages, each unaware of the other. One will marry an Englishman and lead a life of comfort in the palatial rooms of the notorious Cape Coast Castle. The other will be captured in a raid on her village, imprisoned in the very same castle, and shipped off to America to be sold into slavery. HOMEGOING follows the parallel paths of these sisters and their descendants through eight generations: from the slave traders of the Gold Coast to the plantations of Mississippi, from the Asantes’ struggle against British colonialism to the first stirrings of the American Civil War, from the jazz of 20th-century Harlem to the sparkling shores of modern Ghana.