As a young girl growing up in Brooklyn, Claire DeWitt (now a private investigator) and her two best friends, Tracy and Kelly, solved many cases together --- until the day Tracy vanished without a trace. Later, in her 20s, Claire is trying to get her PI license by taking on a cold case that has stumped the LAPD. Today, Claire is on her way to Las Vegas from San Francisco when she’s almost killed by a homicidal driver. In a haze of drugs and injuries, she struggles off the scene, determined to find her would-be killer’s identity --- but the list of people who would be happy to see her dead is not a short one. As these three narratives converge, some mysteries are solved and others continue to haunt.

Though she hasn’t returned since her mentor, Constance Darling, was murdered there, a new case finds tattooed, pot-smoking Claire in post-Katrina New Orleans, where she is investigating the disappearance of a prosecutor known for winning convictions in the homicide-plagued city.