Wendy Doe is a woman with no past and no future. Without any memory of who she is, she’s diagnosed with dissociative fugue, a temporary amnesia that could lift at any moment --- or never at all --- and invited by Dr. Benjamin Strauss to submit herself for experimental observation at his Meadowlark Institute for Memory Research. With few better options, Wendy feels she has no choice. To Dr. Strauss, Wendy is a female body, subject to his investigation and control. To Strauss’ ambitious student, Lizzie Epstein, she’s an object of fascination, a mirror of Lizzie’s own desires, and an invitation to wonder: Once a woman is untethered from all past and present obligations of womanhood, who is she allowed to become?

On Halloween in 1991, a popular high school basketball star ventures into the woods and disappears. Three days later, he’s found with a bullet in his head and a gun in his hand. In the wake of this incident, bright but lonely Hannah Dexter is befriended by the charismatic, seductive Lacey Champlain. Lacey forges a fast, intimate bond with the impressionable Dex, making her over in her own image and unleashing a fierce defiance that neither girl expected. But as Lacey gradually lures Dex away from her safe life into a feverish spiral of obsession, rebellion and ever greater risk, an unwelcome figure appears on the horizon --- and Lacey’s secret history collides with Dex’s worst nightmare.

With her best friend murdered and her boyfriend Max, the main suspect, gone, Nora can barely manage to keep afloat. All she knows is that the entire nightmare is related to the ancient book translation they had been working on for a school project. Then she receives a coded message from Max begging her to join him in Prague. They have a chance to clear his name and finally solve a 400-year-old mystery --- which includes instructions on building a machine to talk to God.