Something is happening to teenagers across America, spreading through memes only they can parse. At the Float Anxiety Abatement Center, in a suburb of Chicago, Simon Oliver is trying to recover from his sister’s tragic passing. He breaks out to join a woman named Louise and a man called The Prophet on a quest as urgent as it is enigmatic. Who lies at the end of the road? A man known as The Wizard, whose past encounter with Louise sparked her own collapse. Their quest becomes a rescue mission when they join up with a man whose sister is being held captive by the Wizard, impregnated and imprisoned in a tower. 

On a foggy summer night, 11 people --- 10 privileged, one down-on-his-luck painter --- depart Martha's Vineyard on a private jet headed for New York. Sixteen minutes later, the unthinkable happens: the plane plunges into the ocean. The only survivors are Scott Burroughs --- the painter --- and a four-year-old boy, who is now the last remaining member of an immensely wealthy and powerful media mogul's family. With chapters weaving between the aftermath of the crash and the backstories of the passengers and crew members, the mystery surrounding the tragedy heightens.

Dr. Paul Allen's specialty is diagnosing patients with conflicting symptoms, patients other doctors have given up on. In the harrowing opening scene of this novel, Dr. Allen is home with his family when a televised news report announces that the Democratic candidate for president has been shot at a rally, and his son Daniel is caught on video as the assassin.