Even though the avatars of New York City have temporarily managed to stop the Woman in White from invading --- and destroying the entire universe in the process --- the mysterious capital "E" Enemy has more subtle powers at her disposal. A new candidate for mayor wielding the populist rhetoric of gentrification, xenophobia and "law and order" may have what it takes to change the very nature of New York itself and take it down from the inside. In order to defeat him, and the Enemy who holds his purse strings, the avatars will have to join together with the other Great Cities of the world in order to bring her down for good and protect their world from complete destruction.

In Manhattan, a young grad student gets off the train and realizes he doesn't remember who he is, where he's from, or even his own name. But he can sense the beating heart of the city, see its history and feel its power. In the Bronx, a Lenape gallery director discovers strange graffiti scattered throughout the city, so beautiful and powerful it's as if the paint is literally calling to her. In Brooklyn, a politician and mother finds she can hear the songs of her city, pulsing to the beat of her Louboutin heels. And they're not the only ones.