Growing up in the White House was never supposed to be easy. So when 16-year-old Cam, also a champion chess player, experiences extreme moodiness and an uncharacteristic violent outburst, doctors are quick to dismiss his troubles as adolescent angst. Still, Secret Service agent Karen Ray is convinced that Cam’s condition is serious --- enough so that she summons her physician ex-husband for a second opinion. At first, the president’s team doesn’t want to listen to Dr. Lee Blackwood. But when Cam gets sicker, Lee must make a diagnosis from a puzzling array of symptoms. As Lee and Karen race for a cure to help Cam, they begin to uncover betrayals that breach the highest levels of national security. And until they can find the truth, no one is safe.

Dr. Julie Devereux is an outspoken advocate for the right to die --- until a motorcycle accident leaves her fiancé, Sam Talbot, a quadriplegic. Sam begs to end his life, but Julie sees hope in a life together. When he passes away from an unexpected heart attack, an autopsy reveals that Sam died of an unusual heart defect, one seen only in those under extreme stress. As Julie investigates similar cases, she finds a frightening pattern…and finds herself the target of disturbing threats. The more cases Julie discovers, the more the threats escalate, until she is accused of a mercy killing of her own. To clear her name and save her career, she must track down whoever is behind these mysterious deaths.

After quitting her residency following two operations gone terribly wrong, Dr. Carrie Bryant learns about an experimental program exploring the use of Deep Brain Stimulation (DBS) that could forever cure the emotional and memory trauma of PTSD. Her first surgery appears to be a success until her patient mysteriously vanishes. When a second patient also goes missing, Carrie employs the investigative skills of reporter David Hoffman, and together they descend into a labyrinth of murder and corruption.

When Dr. Lou Welcome has to fill in last minute for his boss at the Physical Wellness Office, he takes an exclusive tour of the Center for Disease Control. He can't help but wonder about the development of weapons of mass destruction at a bacterial level. Little does Lou know that a scientist working a top-secret case will be kidnapped, and he will become enmeshed in a case that could have fatal consequences across the country.

When respected doctor John Meacham goes on a shooting spree, the blame falls on Dr. Lou Welcome, who worked with Meacham years before as a counselor. And he discovers that Meacham is connected to a conspiracy that may lead to the White House.