A woman arrives alone at a Best Western seeking respite from an emptiness that plagues her. She has fled to the California high desert to escape a cloud of sorrow --- for both her father in the ICU and a husband whose illness is worsening. What the motel provides, however, is not peace but a path, thanks to a receptionist who recommends a nearby hike. Out on the sun-scorched trail, the woman encounters a towering cactus whose size and shape mean it should not exist in California. Yet the cactus is there, with a gash through its side that beckons like a familiar door. So she enters it. What awaits her inside this mystical succulent sets her on a journey at once desolate and rich, hilarious and poignant.

Rachel is 24, a lapsed Jew who has made calorie restriction her religion. By day, she maintains an illusion of existential control, through obsessive food rituals, while working as an underling at a Los Angeles talent management agency. At night, she pedals nowhere on the elliptical machine. Rachel is content to carry on subsisting --- until her therapist encourages her to take a 90-day communication detox from her mother, who raised her in the tradition of calorie counting. Rachel soon meets Miriam, a zaftig young Orthodox Jewish woman who works at her favorite frozen yogurt shop and is intent upon feeding her. Rachel is suddenly and powerfully entranced by Miriam, and as the two grow closer, Rachel embarks on a journey marked by mirrors, mysticism, mothers, milk and honey.

Lucy has been writing her dissertation on Sappho for nine years when she and her boyfriend break up in a dramatic flameout. After she bottoms out in Phoenix, her sister in Los Angeles insists Lucy dog-sit for the summer. But Lucy can find little relief from her anxiety --- not in the Greek chorus of women in her love addiction therapy group, not in her frequent Tinder excursions, not even in Dominic the foxhound's easy affection. Everything changes when Lucy becomes entranced by an eerily attractive swimmer while sitting alone on the beach rocks one night. But when Lucy learns the truth about his identity, their relationship, and Lucy’s understanding of what love should look like, take a very unexpected turn.