After recovering from a serious illness, Stella Sweeney finds out that her neurologist, Dr. Mannix Taylor, has compiled and self-published a memoir about her illness. Her discovery comes when she spots a photo of the finished copy in an American tabloid --- and it’s in the hands of the vice president’s wife! As her relationship with Dr. Taylor gets more complicated, Stella struggles to figure out who she was before her illness, who she is now, and who she wants to be while relocating to New York City to pursue a career as a newly minted self-help memoirist.

As the youngest of the five Walsh girls, Helen has had a tough time finding her way in the world. Her hunky new boyfriend, Artie, and his three adorable children are a great distraction, but his beautiful ex-wife lives a little too close for comfort. Meanwhile, Helen runs into her ex-boyfriend Jay Parker and reluctantly signs on to help him locate Wayne Diffney, the recently disappeared fourth member of Ireland’s biggest mid-’90s boy band.