While checking on a former patient at her isolated Victorian house, Dr. Amy Winslow discovers in the cellar a secret, cobweb-covered 1899 electrochemical laboratory containing a Jules Verne-esque steam-punk sarcophagus out of which springs a wild-eyed, half-mummified, crypt-keeper-like man. He claims to be a real-life Victorian master chemist and detective named Holmes, who allowed Conan Doyle to write stories based on his cases. Holmes and his reluctant new Watson, Amy, find themselves unexpectedly attracted to each other while perilously involved in reclaiming his proof of identity. It’s all connected to a horrific death-by-tiger, only the first of several bizarre, mystifying murders being committed by an exquisitely fiendish descendant of Holmes’ Victorian archenemy, Professor Moriarty.