In Locksburg, Pennsylvania, a former coal and steel town whose best days seem long past, 5,000 residents have toughed it out. For some of them, their biggest troubles have just arrived. After years of just scraping by, three restless souls have their lives upended: Nathan, a volunteer fireman who uncovers a secret stash of money in a burning building and takes it; Callie, a nurse whose tender patient may not have long to live, despite the girl’s fundamentalist parents’ ardent beliefs; and Andy, a recovering heroin addict who undertakes a nightmare mission to hunt down and stop a serial predator. As their stories barrel toward unexpected ends, Nathan, Callie and Andy struggle to endure --- or escape. They each face their pasts and gamble on their futures, and confront the underside of their rough Rust Belt town.