In 2003, at the prestigious Brookfield Conservatory in Boston, a chance encounter sparks an inimitable friendship between driven pianist and singer Anna Buckley and composer wunderkind Will Pendleton. But soon after graduation, one night forever alters the trajectory of their lives, destroying their relationship in the process. Twenty years later in New York, 16-year-old piano virtuoso Lottie Thomas is grappling with the rigors of her elite prep school and the confounding disappearance of the woman who gave her up at birth. When Lottie suddenly discovers the startling truth of her identity, the revelation catalyzes a chain of events that not only reunites Lottie with her birth parents, but forces them together on a rock tour bus for a careening cross-country journey, where they finally must reconcile with irrevocable choices from the past.