Ohio-born Pru Steiner arrives in New York in 1976. When she falls in love with and marries Spence Robin, her hotshot young Shakespeare professor, her life takes a turn she couldn’t have anticipated. Thirty years later, something is wrong with Spence. With their daughter, Sarah, away at medical school, Pru must struggle on her own to care for him. One day, feeling especially isolated, Pru meets a man, and the possibility of new romance blooms. Meanwhile, Spence’s estranged son from his first marriage has come back into their lives. Arlo, a wealthy entrepreneur who invests in biotech, may be his father’s last, best hope.

On July 4, 2005, the Frankel family descends upon their summer home in the Berkshires for a memorial to Leo, the youngest Frankel sibling, who was killed while on assignment in Iraq a year before. Over the course of three days, the Frankels will contend with sibling rivalries and marital feuds, volatile women and silent men, and, ultimately, the true meaning of family.