In September of 1890, the academic year begins at the Carlisle School, founded and run by Captain Richard Henry Pratt. Pratt's motto, “To save the man, we must kill the Indian,” is severely enforced in both classroom and dormitory: Speak only English, forget your own language and customs, learn to be white. As the young students navigate surviving the school, they begin to hear rumors of a “ghost dance” amongst the tribes of the west --- a ceremonial dance aimed at restoring the Native People to power, and running the invaders off their land. As the hope and promise of the ghost dance sweeps across the Great Plains, cynical newspapers seize upon the story to whip up panic among local whites. As news of these developments reaches Carlisle, each student, no matter what their tribe, must make a choice: to follow the white man’s path, or be true to their own way of life.

It begins in the highlands of Scotland in 1746, at the Battle of Culloden, the last desperate stand of the Stuart “pretender” to the throne of the Three Kingdoms, Bonnie Prince Charlie, and his rabidly loyal supporters. Vanquished with his comrades by the forces of the Hanoverian (and Protestant) British crown, the novel’s eponymous hero, Jamie MacGillivray, narrowly escapes a roadside execution only to be recaptured by the victors and shipped to Marshalsea Prison, where he cheats the hangman a second time before being sentenced to transportation and indentured servitude in colonial America "for the term of his natural life." His travels are paralleled by those of Jenny Ferguson, a poor village girl swept up on false charges by the English and also sent in chains to the New World.