On her wedding day in San Juan, Puerto Rico, in 1968, Rafaela Acuña y Daubón has mild misgivings, but she marries Peter Brennan Jr. anyway in a blaze of romantic optimism. She has no way of knowing how dramatically her life will change when she uproots her young family to start over in the American Midwest, unleashing a fleet of disappointments. In the 1980s, against the backdrop of her mother’s isolation in St. Louis, Missouri, Rafaela’s daughter, Ruth, wants only to belong. Eager to fit in, Ruth lets go of her language, habits and childhood memories of Puerto Rico. It’s not until decades later when Ruth’s own daughter, Daisy, returns to San Juan that her mother and grandmother begin to truly reflect on the choices that have come to define their lives.

Lydia lives in Acapulco. She has a son, Luca, the love of her life, and a wonderful husband who is a journalist. And while cracks are beginning to show in Acapulco because of the cartels, Lydia’s life is, by and large, fairly comfortable. But after her husband’s tell-all profile of the newest drug lord is published, none of their lives will ever be the same. Forced to flee, Lydia and Luca find themselves joining the countless people trying to reach the United States. Lydia soon sees that everyone is running from something. But what exactly are they running to?