Agrigento, Sicily, 1883. With the orsine destroyed, Cairndale lies in ruins, and Marlowe has vanished. His only hope of rescue lies in a fabled second orsine --- long-hidden, thought lost --- which might not even exist. But when a body is discovered in the shadow of Cairndale, a body wreathed in the corrupted dust of the drughr, Charlie and the Talents realize there is even more at stake than they'd feared. For a new drughr has arisen, ferocious, horned, seemingly able to move in their world at will --- and it is not alone. A malevolent figure, known only as the Abbess, desires the dust for her own ends. And deep in the world of the dead, a terrible evil stirs --- an evil that the corrupted dust just might hold the secret to reviving or destroying forever.

Despite surviving a brutal childhood in Mississippi, Charlie Ovid doesn't have a scar on him. His body heals itself, whether he wants it to or not. Marlowe, a foundling from a railway freight car, shines with a strange bluish light. He can melt or mend flesh. When Alice Quicke, a jaded detective with her own troubled past, is recruited to escort them to safety, all three begin a journey into the nature of difference and belonging, and the shadowy edges of the monstrous. What follows is a story of wonder and betrayal, from the gaslit streets of London and the wooden theaters of Meiji-era Tokyo, to an eerie estate outside Edinburgh where other children with gifts are forced to combat the forces that threaten their safety. There, the world of the dead and the world of the living threaten to collide.