A wedding reception is coming to a close in the Hollywood Hills when the blissful day is shattered by the death of one of the newlyweds. Though the incident appears to be an accident, Homeland Security Investigations agent Carmen Sanchez and her partner, security expert Jake Heron, discover that the tragedy is the third in a series of similar deaths and conclude something far more sinister is at play. The two uncover chilling evidence pointing to a serial killer who has taken evil to the next level. Dubbed the Honeymoon Killer, this man isn’t interested in his victims but in creating his own macabre masterpiece from their graves --- focused on the survivors and reveling in their grief. And now his dark obsession has turned to Carmen and Jake. Time is running out as a deadly game between predator and prey begins.

Carmen Sanchez is a tough Homeland Security agent who plays by the rules. But when her sister is attacked, revealing a connection to a series of murders across Southern California, she realizes that a conventional investigation will not be enough to stop the ruthless perpetrator. With nowhere else to turn, Sanchez enlists the aid of Professor Jake Heron, a brilliant and quirky private security expert who believes rules are merely suggestions. The two have a troubled past, but he owes her a favor. They team up to catch the assailant, who has no discernible motive and fits no classic criminal profile. All they have to go on is a distinctive tattoo and a singular obsession that gives this chillingly efficient tactician his nickname: Spider. Over the next 72 hours, Sanchez and Heron find themselves in the midst of a lethal chess match with the killer as they race to stop the carnage.