1940. Lili and Esti have been best friends since meeting at the University of Ferrara; when Esti’s son Theo is born, they become as close as sisters. There is a war being fought across borders, and in Italy, Mussolini’s Racial Laws have deemed Lili and Esti descendants of an ‘inferior’ Jewish race, but life somehow goes on --- until the friends find themselves in occupied territory. Esti, older and fiercely self-assured, convinces Lili to flee to a convent in Florence, where they pose as nuns and forge false identification papers for the Underground. When disaster strikes at the convent, a critically wounded Esti asks Lili to take a much bigger step: To go on the run with Theo. Terrified to travel on her own, Lili sets out on an epic journey south toward Allied territory, through Nazi-occupied villages and bombed-out cities, doing everything she can to keep Theo safe.

It is the spring of 1939, and three generations of the Kurc family are doing their best to live normal lives, even as the shadow of war grows closer. But soon the horrors overtaking Europe will become inescapable, and the Kurcs will be flung to the far corners of the world, each desperately trying to navigate his or her own path to safety. As one sibling is forced into exile, another attempts to flee the continent, while others struggle to escape certain death. Driven by an unwavering will to survive and by the fear that they may never see one another again, the Kurcs must rely on hope, ingenuity and inner strength to persevere.