Edwin St. Andrew is 18 years old when he crosses the Atlantic by steamship, exiled from polite society following an ill-conceived diatribe at a dinner party. He enters the Canadian wilderness and suddenly hears the notes of a violin echoing in an airship terminal. Two centuries later, Olive Llewellyn is on a book tour. She’s traveling all over Earth, but her home is the second moon colony. Within the text of Olive’s bestselling pandemic novel lies a strange passage: a man plays his violin for change in the echoing corridor of an airship terminal as the trees of a forest rise around him. When Gaspery-Jacques Roberts, a detective in the black-skied Night City, is hired to investigate an anomaly in the North American wilderness, he uncovers a series of lives upended.

Vincent is a bartender at the Hotel Caiette, a five-star lodging on the northernmost tip of Vancouver Island. On the night she meets Jonathan Alkaitis, a hooded figure scrawls a message on the lobby's glass wall: "Why don't you swallow broken glass." High above Manhattan, a greater crime is committed: Alkaitis is running an international Ponzi scheme, moving imaginary sums of money through clients' accounts. When the financial empire collapses, it obliterates countless fortunes and devastates lives. Vincent, who had been posing as Jonathan's wife, walks away into the night. Years later, a victim of the fraud is hired to investigate a strange occurrence: a woman has seemingly vanished from the deck of a container ship between ports of call.

One snowy night, a famous Hollywood actor slumps over and dies onstage during a production of King Lear. Hours later, the world as we know it begins to dissolve. STATION ELEVEN charts the strange twists of fate that connect five people: the actor, the man who tried to save him, the actor's first wife, his oldest friend, and a young actress with the Traveling Symphony, caught in the crosshairs of a dangerous self-proclaimed prophet.