It’s 1949, and South Philadelphia bursts with opportunity during the post-war boom. The Palazzini Cab Company & Western Union Telegraph Office, owned and operated by Dominic Palazzini and his three sons, is flourishing. But a decades-long feud that split Dominic and his brother, Mike, and their once-close families sets the stage for a re-match. Amidst the hoopla, the arrival of an urgent telegram from Italy upends the life of Nicky Castone (Dominic and his wife’s orphaned nephew) who lives and works with his Uncle Dom and his family. Nicky decides, at 30, that he wants more.

The story begins in 1962. On the sun-drenched Italian coastline, a young innkeeper looks out over the incandescent waters of the Ligurian Sea and spies a tall, thin woman approaching him on a boat. She is an actress, an American starlet, and she is dying. And the story begins again today when an elderly Italian man shows up on a movie studio's back lot --- searching for the mysterious woman he last saw at his hotel decades earlier.