When two young lovers abscond from a Puritan colony, little do they know that their humble cabin in the woods will become the home of an extraordinary succession of human and nonhuman characters alike. An English soldier, destined for glory, abandons the battlefields of the New World to devote himself to growing apples. A pair of spinster twins navigate war and famine, envy and desire. A crime reporter unearths an ancient mass grave --- only to discover that the earth refuses to give up their secrets. A lovelorn painter, a sinister con man, a stalking panther, a lusty beetle: As the inhabitants confront the wonder and mystery around them, they begin to realize that the dark, raucous, beautiful past is very much alive.

On a fateful flight, a balloonist makes a discovery that changes her life forever. A telegraph operator finds an unexpected companion in the middle of the Amazon. A doctor is beset by seizures, in which he is possessed by a second, perhaps better, version of himself. And in Regency London, a bare-knuckle fighter prepares to face his most fearsome opponent, while a young mother seeks a miraculous cure for her ailing son. From the Nile's depths to the highest reaches of the atmosphere, from volcano-racked islands to an asylum on the outskirts of Rio de Janeiro, these are tales of ecstasy, epiphany, and what the New York Times Magazine called the "struggle for survival…hand to hand, word to word."

Lucius is a 22-year-old medical student when World War I explodes across Europe. He enlists, expecting a position at a well-organized field hospital. However, upon his arrival, he discovers a freezing outpost ravaged by typhus. The other doctors have fled, and only a mysterious nurse named Sister Margarete remains. But Lucius has never lifted a surgeon's scalpel. And as the war rages across the winter landscape, he finds himself falling in love with the woman from whom he must learn a brutal makeshift medicine. Then one day, an unconscious soldier is brought in from the snow. He seems beyond rescue, until Lucius makes a fateful decision that will change the lives of doctor, patient and nurse forever.