On the Great Plains of Oklahoma, in the heart of the Cherokee Nation, a strange atmospheric disturbance is noticed by Jim Hardgray, a down-on-his-luck single father trying to reconnect with his teenage daughter, Tawny. At NASA’s headquarters in Houston, Texas, astrophysicist Dr. Mikayla Johnson observes an interaction with the Voyager 1 spacecraft on the far side of the solar system, and she concludes that something enormous and unidentified is heading directly for Earth. And in an undisclosed bunker somewhere in the United States, an American threat forecaster known only as the Man Downstairs intercepts a cryptic communication and sends a message directly to the president and highest-ranking military brass: “First contact imminent.”

Deep inside Fairchild Air Force Base, Project Eternal Vigilance has continued to watch and wait for the Andromeda Strain to reappear. On the verge of being shut down, the project has registered no activity --- until now. A Brazilian terrain-mapping drone has detected a bizarre anomaly of otherworldly matter in the middle of the jungle and, worse yet, the tell-tale chemical signature of the deadly microparticle. With this shocking discovery, the next-generation Project Wildfire is activated, and a diverse team of experts hailing from all over the world is dispatched to investigate the potentially apocalyptic threat. If they can’t reach the quarantine zone, enter the anomaly and figure out how to stop it, this new Andromeda Evolution will annihilate all life as we know it.

Deep inside Fairchild Air Force Base, Project Eternal Vigilance has continued to watch and wait for the Andromeda Strain to reappear. On the verge of being shut down, the project has registered no activity --- until now. A Brazilian terrain-mapping drone has detected a bizarre anomaly of otherworldly matter in the middle of the jungle and, worse yet, the tell-tale chemical signature of the deadly microparticle. With this shocking discovery, the next-generation Project Wildfire is activated, and a diverse team of experts hailing from all over the world is dispatched to investigate the potentially apocalyptic threat. If they can’t reach the quarantine zone, enter the anomaly and figure out how to stop it, this new Andromeda Evolution will annihilate all life as we know it.

People are implanted with a device that makes them capable of superhuman feats. The powerful technology has profound consequences for society, and soon a set of laws is passed that restricts the abilities --- and rights --- of "amplified" humans. On the day that the Supreme Court passes the first of these laws, twenty-nine-year-old Owen Gray joins the ranks of a new persecuted underclass known as "amps." Owen is forced to go on the run, desperate to reach an outpost in Oklahoma where, it is rumored, a group of the most enhanced amps may be about to change the world --- or destroy it.

Not far into our future, the global network of machines on which our world has grown dependent suddenly becomes an implacable, deadly foe. At the moment the robots attack, the human race is almost annihilated. But as its scattered remnants regroup, humanity for the first time unites in a determined effort to fight back.