The three Blue sisters are exceptional --- and exceptionally different. Avery, the eldest and a recovering heroin addict turned strait-laced lawyer, lives with her wife in London; Bonnie, a former boxer, works as a bouncer in Los Angeles following a devastating defeat; and Lucky, the youngest, models in Paris while trying to outrun her hard-partying ways. They also had a fourth sister, Nicky, whose unexpected death left the family reeling. A year later, as they each navigate grief, addiction and ambition, they find they must return to New York to stop the sale of the apartment in which they were raised. As the sisters reckon with the disappointments of their childhood and the loss of the only person who held them together, they realize that the greatest secrets they’ve been keeping might not have been from one another but from themselves.

Twenty-four-year-old British painter Cleo has escaped from England to New York and is still finding her place in the sleepless city when, a few months before her student visa ends, she meets Frank. Twenty years older and a self-made success, Frank's life is full of all the excesses Cleo's lacks. He offers her the chance to be happy, the freedom to paint and the opportunity to apply for a Green Card. But their impulsive marriage irreversibly changes both their lives, and the lives of those close to them, in ways they never could've predicted.