Born in Michigan in the early 1940s to a taciturn mother and embittered father, Lottie Kristin is independent from the start, fascinated with the mysteries of nature and the human body. By age 16, she and her sweetheart, cheerful high school sports hero Charlie Hart, have been through a devastatingly traumatic pregnancy. When an injury ends Charlie's football career four years later, the two move to Texas hoping for a fresh start. There, torn between the vitality of the antiwar movement and her family's traditional values, Lottie discovers the joys of motherhood, and reconnects with her interest in biology and experimentation, taking a job as a lab technician. While Charlie's depression pervades their home, Lottie's instinct is toward life.