After years of personal and professional turmoil, things are finally looking up for Columbus, Ohio, private eye Andy Hayes. As SICK TO DEATH opens, Andy is relishing his new gig: a drama-free, family-friendly stint as a guard at the Columbus Museum of Art. However, Andy’s newfound equilibrium comes crashing down when he interrupts the theft of a painting by famed Ashcan school realist George Bellows --- and is promptly fired for breaking museum protocols. Helping him thwart the robbers is Alex Rutledge, the adult daughter he never knew he had, the result of a one-night stand during his misspent youth a quarter century earlier. Alex wants to hire her newly discovered father to find the driver who killed her mother five months earlier in a still unsolved hit-skip accident.

Myles’ courtroom testimony should have put Pryor, their one-eyed ringleader, behind bars after the bank robbery gone wrong, yet somehow Pryor got off scot-free while Myles served time. Now, upon his release, Myles decides he is done with his life of wrongdoing --- a change that will only be possible if he can kill Pryor and turn over a new leaf. Pryor has other ideas, and the collision between these two deadly forces soon leaves the ex-con in critical condition. With Myles in recovery, it’s up to his girlfriend, Penny, to avenge her lover and salvage their chance at normalcy. As Pryor and his cronies prepare for their biggest score yet --- targeting a vulnerable small-town Ohio bank on a day when Amish farmers arrive with hefty cash deposits --- Penny is hot on their heels. But is she prepared for the carnage Pryor will gleefully wreak on the path to his prize?