At 40, Peter, an asylum lawyer in New York City, is overworked and isolated. He spends his days immersed in the struggles of immigrants only to return to an empty apartment and occasional hook-ups with a man who wants more than Peter can give. But when the asylum case of a young gay man pierces Peter's numbness, the event that he has avoided for 20 years returns to haunt him. Ann, his mother, who runs a women's retreat center she founded after leaving his father, is hurt by the estrangement from Peter but cherishes the world she has built. She long ago put behind her the decision that divided her from her son. But as Peter’s case plunges him further into the fraught memory of his first love and the night of violence that changed his life, he and his mother must confront the secret that tore them apart.

When Margaret's fiancé, John, is hospitalized for depression in 1960s London, she faces a choice: carry on with their plans despite what she now knows of his condition, or back away from the suffering it may bring her. She decides to marry him. IMAGINE ME GONE is the story of what unfolds from this act of love and faith. At the heart of it is their eldest son, Michael, a brilliant, anxious music fanatic who makes sense of the world through parody. Over the span of decades, his younger siblings struggle along with their mother to care for his increasingly troubled and precarious existence.