Harvard graduate student Connie Goodwin needs to spend her summer doing research for her doctoral dissertation. But when her mother asks her to handle the sale of Connie's grandmother's abandoned home near Salem, she can't refuse. As she is drawn deeper into the mysteries of the family house, Connie discovers an ancient key secreted within a 17th-century Bible. The key contains a yellowing fragment of parchment with a name written upon it: Deliverance Dane. This discovery launches Connie on a quest to find out who this woman was, and to unearth a rare colonial artifact of singular power: a physick book, its pages a secret repository for lost knowledge of herbs and other, stranger things.