The body of a young woman found in an Arizona border town, presumed to be an illegal immigrant, disappears from the town morgue. Then more bodies, dead from an inexplicable disease that solidified their blood, are brought to the morgue, only to also vanish. Soon, the U.S. government must come to terms with what they're too late to stop: an epidemic of vampirism. These changed people, or "Gloamings," rapidly rise to prominence in all aspects of modern society. Soon people are beginning to be "re-created," willingly accepting the risk of death if their bodies can't handle the transformation. But when a charismatic and wealthy businessman who recently has been turned, runs for political office, all hell breaks loose.