Jessica Fletcher’s British cousin, Emma MacGill, will be traveling to Edmonton in Alberta, Canada, to perform with international star Derek Braverman in an old-fashioned musical revue. Emma would love for Jessica to join her there and suggests she bring along some friends. Having just finished her latest book, Jessica is ready for a vacation and is delighted to agree. Dr. Seth Hazlitt and Sheriff Mort Metzger are huge fans of Braverman, so they are eager to tag along. Upon arrival in Edmonton, Jessica is quickly outed as mystery writer J. B. Fletcher, and despite numerous protests, a hotel staffer arranges a book signing for her. When a hotel bartender, who also happens to be a stagehand for Emma’s play, turns up dead backstage at the theater, Jessica’s fun and relaxing vacation quickly becomes anything but.

Evelyn Phillips, the former editor of the Cabot Cove Gazette, is back in Cabot Cove. Evelyn tells Jessica and Seth that she got a couple of really weird notes from Bertha Mae Cormier, so she’s come back to town to check on her old friend. Jessica does become somewhat concerned when Bertha Mae starts to talk about her new neighbor, Martin Terranova, who teaches yoga and meditation in his pool house. Jessica attends one of his classes and notices that Terranova is flirtatious with several elderly clients, especially Bertha Mae. Evelyn is becoming convinced that Terranova is after Bertha Mae’s money. A short while later, Martin turns up dead in his weight room. What at first blush seems to be an accident soon proves to be murder, and Evelyn becomes the prime suspect.

Jessica Fletcher is quick to accept an invitation to replace a speaker who couldn’t attend a book festival in Belfast, Ireland. When her Cabot Cove neighbor, Maeve O'Bannon, hears about the trip, she asks Jessica to deliver some paintings to her family in the village of Bushmills. Happy to extend her travels and see more of the Irish countryside, Jessica agrees. The festival goes off without a hitch, and it seems like Jessica is in for a relaxing vacation. But then Maeve’s cousin, Michael, is discovered dead under suspicious circumstances. Jessica finds herself once again in the midst of a murder investigation, and she’ll have to dig into the O'Bannon family’s secrets to unmask the killer.

Jessica Fletcher is delighted when her nephew, Grady, invites her to spend a few days with his family in an oceanside New York bungalow. She packs her bags and heads down to the city, ready to spend some quality time with Grady; his wife, Donna; and their young son, Frank. But the morning after Jessica’s arrival, Donna finds her boss dead on a tennis court, and Jessica’s dreams of a relaxing visit are quashed. Everyone in the small beachside community is a suspect, and the local authorities --- headed by an old colleague of Cabot Cove sheriff Mort Metzger --- have asked that no one leave town. Will Jessica be able find a killer and salvage the rest of her trip?

When Nelson Penzell, the co-owner of a local art and treasure store in Cabot Cove, is murdered, the nail tech from Jessica Fletcher's favorite beauty parlor is the main suspect. After all, she's the one who ran out of the store screaming, covered in blood and holding the murder weapon. Jessica is positive that Coreen can't possibly be guilty and is determined to prove it. When Michael Haggerty, a handsome MI-6 agent and Jessica's old friend, is caught snooping around the victim’s home, it's quickly apparent to her that she was right. Nelson has always had a bit of a reputation for being a rake, but Haggerty is sure his sins go far beyond what anyone in town imagined.

After traveling to Bethesda for a mystery writers’ conference, Jessica Fletcher decides she’s earned a vacation and takes a train to Columbia, South Carolina, to visit her old college friend Dolores, who has recently married her third husband, Willis Nickens, a wealthy and cutthroat businessman. They’ve moved into an opulent historic home with plenty of space for guests, and Jessica is ready for a week of shopping, gossiping and relaxing at the grand estate. But the morning after she arrives, Jessica discovers Willis face down in the koi pond, and despite what the police think, she’s sure foul play is involved. She hadn’t known Willis long, but it’s clear to her that he didn’t concern himself with making friends. The question isn’t if her friend’s husband was murdered but by whom.

With work on the reconstruction of her beloved home almost complete, Jessica Fletcher is in high holiday spirits. The only thing dampening the holiday cheer is the discovery of two sets of bones on Jessica’s property: one set ancient, the other only about a year old. It’s concluded that they were both placed there during the reconstruction, and Jessica suspects that, despite the centuries between them, the remains might be connected. Soon tabloid reporter Tad Hollenbeck arrives in Cabot Cove to write a story about what he calls “the murder capital of the country.” But when Tad himself is murdered, Jessica speculates that his arrival, his death and the discovery of the bones are all somehow linked.

Still staying at the Hill House hotel while her beloved home is being rebuilt, Jessica Fletcher finds herself sharing the space for a weekend with a dozen members of a wedding party who have gathered there for a rehearsal dinner. The families of the bride and groom can't stand each other but have agreed to put aside years of long-simmering tension to celebrate the nuptials. Unfortunately, weather forecasters underestimated the severity of a storm that turns into a historic blizzard that dumps nearly five feet of snow on Cabot Cove, leaving everyone stranded. But the hotel guests have bigger things to worry about than bad weather conditions, because a murderer has shown up uninvited --- one who has vowed to take them down one by one.

Young Jessica Fletcher's life couldn't be more ordinary. She teaches at the local high school while she and her loving husband, Frank, are raising their nephew, Grady, together. But when the beloved principal dies under mysterious circumstances, Jessica knows something is off and, for the very first time, investigates a death. Present-day Jessica returns to high school for a colleague's retirement party and has fun seeing familiar faces. That is, until the colleague winds up dead --- and his death has mysterious links to Jessica's very first murder case. With nothing but her own instincts to guide her, Jessica embarks on a quest to find out what really happened all those years ago and who's behind these murders.

Jessica Fletcher's favorite gin rummy partner, Mimi Van Dorn, checks into the brand-new Clifton Care Partners, a private hospital that's just opened up shop in town, for a simple procedure --- one that leads tragically, and inexplicably, to her death. Seeking justice in her inimitable fashion, Jessica decides to pursue her own investigation on the hospital and its shadowy business dealings. On the trail of what initially appears to be medical malpractice, Jessica digs deeper and learns her friend was actually a victim of something far more sinister. Death is bad for business, but murder is even worse, and Jessica will find plenty of both as she races to bring down Clifton Care Partners before someone else flatlines.

Jessica Fletcher has had plenty to worry about over her storied career, as both a bestselling novelist and an amateur sleuth. But she never had any reason to worry about her longtime publisher, Lane Barfield, who also happens to be a trusted friend. When mounting evidence of financial malfeasance leads to an FBI investigation of Lane, Jessica can't believe what she's reading. So when Barfield turns up dead, Jessica takes on the task of proving Barfield's innocence --- she can't fathom someone she's known and trusted for so long cheating her. Sure enough, Jessica's lone wolf investigation turns up several oddities and inconsistencies in Barfield's murder. Jessica knows something is being covered up, but what exactly?

Jessica Fletcher takes up the case of her good friend, Barbara "Babs" Wirth, after Babs' husband, Hal, suffers a fatal heart attack that Jessica has reason to believe was actually murder. At the heart of her suspicions lies a sinister dating site Hal had used while he and Babs were having marital issues, a site that may be complicit in somehow swindling him out of millions. Jessica's investigation reveals that Hal was far from the only victim, and when his former business partner is also killed, a deadly pattern emerges. Jessica teams up with a brilliant young computer hacker to follow the trail, but as she gets closer to the truth, two near misses force her to realize that she may very well be the next victim.